The design and implementation of monolithic and hybrid sensors using integrated circuits, particularly in CMOS is presented. Performance metrics of sensors will be defined. The advantages and shortcomings of sensors built in silicon-based fabrication processes will be analyzed. A comprehensive study of the design and analysis of CMOS integrated image sensors, integrated biosensors and electronic backbone of MEMS hybrid sensors including silicon photodetectors; CCD and CMOS sensor architectures and circuits; affinity-based detection and biochemical transduction, integrated microarrays, biochips and sensor SoCs will be studied.